I've been DB for 20 years. I ran knobs forever. I decided to try the MT43 after talking to a few other riders a few years ago. I've run nothing else on my rear tire for 3 plus years.
What I found. Its DOT (street legal.) When its slippery, everyone in the group is sliding. Doesn't matter what your running. The only downfall I found is cornering without a brim. No brim, it doesn't hookup like a knobby will. You need to change your riding style a little. How? I changed to a trails to be more trail friendly. Face it now or later, things are changing. So, instead of accelerating out of corners and locking the rear tire into corners, I've smoothed my throttle control out. The tire is great for technical stuff. Wet technical stuff. It lasts pretty long. I'm a B rider. 54 years old. I'm still moving pretty fast and can sometimes stay up with my faster friends. But its not because of the tire. Its a really good tire and pretty much the only rear tire I run. Oh ya, it worked ok in sand. I don't like sand or ride in the desert, so its not a issue for me. But I suspect, a good knobby will serve riders better in deep sand.